Isolated myelosarcoma development in an adolescent chronic myeloid leukemia patient with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36).

Ören H., Yılmaz Ş., Sercan Z., Demircioglu F., Yueksel E., Irken G.

Cancer genetics and cytogenetics, cilt.182, sa.1, ss.43-5, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 182 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.cancergencyto.2007.12.006
  • Dergi Adı: Cancer genetics and cytogenetics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.43-5
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Additional chromosomal abnormalities are found in 5-20% of patients during chronic phase of chronic myeloid leukemia and in 60-80% preceding or accompanying blast crisis. These abnormalities are important in disease progression and, because they may occur before hematological and clinical symptoms, can be taken as a prognostic indicator. An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in bone marrow examinations and then developed isolated myelosarcoma I year after onset, with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36). (C) 2008 Elsevier Inc. All rights reserved.