Herpetic Keratouveitis following Intravitreal Ranibizumab Injection in a Case with Diabetic Macular Edema

ÖZTÜRK A. T., ARIKAN G., Oner H.

OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.29, sa.7-8, ss.1645-1647, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7-8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/09273948.2020.1767793
  • Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1645-1647
  • Anahtar Kelimeler: Diabetic macular edema, herpes simplex virus, herpetic keratouveitis, intravitreal injection, ranibizumab, KERATITIS, BEVACIZUMAB, SIMPLEX
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose The purpose of this study is to report a case of herpetic keratouveitis that developed soon after intravitreal ranibizumab injection. Case Report A 54-year-old man with bilateral proliferative diabetic retinopathy and severe macular edema received intravitreal ranibizumab injections in both eyes within 3 days interval. One week after the injection, patient presented with acute vision loss in his right eye. Slit-lamp biomicroscopy revealed diffuse corneal edema and severe flare in the anterior chamber with intraocular pressure (IOP) rise. After epithelial dendritic corneal ulcer was visualized, he was diagnosed with right herpetic keratouveitis that was treated with oral valacyclovir, as well as topical acyclovir ointment and prednisolone acetate drops. However, recalcitrant IOP rise had to be treated with a single session transscleral diode laser cyclophotocoagulation. Conclusion Herpetic keratouveitis can be seen as a rare complication of intravitreal ranibizumab injection. To our best knowledge, this is the first case with herpes keratouveitis developed following intravitreal ranibizumab injection.