Design of orthopedic support material containing diclofenac sodium microparticles: preparation and characterization of microparticles and application to orthopedic support material

SARIIŞIK A. M., ARICI M., Topbas O., KARAVANA S. Y., Ozturk C., Ertan G.

TEXTILE RESEARCH JOURNAL, cilt.83, sa.10, ss.1030-1043, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83 Sayı: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1177/0040517512464292
  • Dergi Adı: TEXTILE RESEARCH JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1030-1043
  • Anahtar Kelimeler: Microencapsulation, spray drying, diclofenac sodium, orthopedic support materials, RELEASE, MICROENCAPSULATION, DELIVERY, FORMULATION, TECHNOLOGY, SYSTEM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study is preparation and characterization of diclofenac sodium microparticles and their application to the orthopedic support materials. The microparticles were obtained using spray drying method involving ethyl cellulose as shell material. The morphology, particle size, drug loading capacity and in vitro release characteristics of the drug microparticles were optimized for impregnation diclofenac sodium microparticles onto the orthopedic support materials. Scanning electron microscopy (SEM) was used to characterize the drug microparticles and the treated fabrics with microparticles. SEM images illustrated that the microparticles were spherical in shape and also fixed onto the orthopedic support materials. Furthermore, the resistance of materials containing microparticles to washing were also investigated. Finally, in vitro drug release studies of microparticles and textile impregnated with microparticles were done. This study suggested that textile systems containing diclofenac sodium microparticles could have a potential for long-term therapy for rheumatic disorders.