The tectonic regime of Eastern Anatolia is determined by the Arabia-Eurasia continent-continent collision. Several dynamic models have been proposed to characterize the collision zone and its geodynamic structure. In this study, change in crustal thickness has been investigated using gravity, magnetic and topographic data of the region. In the first stage, two-dimensional low-pass filter and upward analytical continuation techniques were applied to the Bouguer gravity data of the region to investigate the behavior of the regional gravity anomalies. Next the moving window power spectrum method was used, and changes in the probable structural depths from 38 to 52 km were determined. The changes in crustal thickness where free air gravity and magnetic data have inversely correlated and the type of the anomaly resources were investigated applying the Euler deconvolution method to Bouguer gravity data. The obtained depth values are consistent with the results obtained using the power spectrum method. It was determined that the types of anomaly resources are different in the west and east of the 40 degrees E longitude. Finally, using the obtained findings from this study and seismic velocity models proposed for this region by previous studies, a probable two-dimensional crust model was constituted.