Multicentric Plasma Cell Type of Castleman Disease in a Child: Difficulty in Diagnosis and Treatment

Karapinar T. H., TÜFEKÇİ Ö., Gozmen S., YILMAZ Ş., Irken G., ÖREN H.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.35, no.7, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1097/mph.0b013e31829cdd2a
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Castleman disease, childhood, plasma cell, LYMPH-NODE HYPERPLASIA, MANIFESTATION, TOCILIZUMAB
  • Dokuz Eylül University Affiliated: Yes

Abstract

Multicentric plasma cell variant of Castleman disease (CD) has rarely been reported and the optimal therapeutic approach is unknown, especially in childhood. In this case report, we discuss the case of a 7-year-old boy with multicentric plasma cell variant of CD, who presented with cervical lymphadenopathies, autoimmune hemolytic anemia, bone marrow insufficiency, pulmonary, renal, hepatic, and gastrointestinal involvement, emphasizing the difficulty in diagnosis and treatment approach.