Mild-intensity Exercise Tract Via Both Hypoxic Triggers VEGF in the Digestive and Nonhypoxic Mechanisms

Hosgorler F. U., KIZILDAĞ S., Koc B., YÜKSEL O., Kirik A. B. T., Ilgin R., ...Daha Fazla

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, cilt.63, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1590/1678-4324-2020200059
  • Dergi Adı: BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: exercise, gastrointestinal, hypoxia, VEGF, ENDOTHELIAL GROWTH-FACTOR, BLOOD-FLOW, GASTROINTESTINAL-TRACT, OXIDATIVE STRESS, ANGIOGENESIS, HYPERTENSION, EXPRESSION, DISEASE, RATS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Hypoxia occurs in the splanchnic region during exercise associated with sympathetic activity. In the elderly, vascular insufficiency and low vascular endothelial growth factor (VEGF) expression are observed. Compared to young people, sympathetic signals of older individuals are blunted and more resistant to splanchnic blood flow alterations during exercise. VEGF induces vasodilation responses and hence may retain blood in the splanchnic vascular bed. We hypothesized that regular mild-intensity exercise triggers weak VEGF expression in the digestive tract of the elderly. The effects of exercise on the levels of VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) in the stomach, jejunum, ileum and colon tissues were evaluated. With exercise, the VEGF levels in the stomach and colon increased. Although the SOD, GPx, and MDA levels decreased in stomach, they increased in the colon. T-AOC increased in the stomach and there was no change in the jejunum, ileum and colon. The hypoperfusion during exercise was not equal in all regions of the gastrointestinal tract in the aged subjects. Hypoxia and other exercise-related mechanisms could have led to this VEGF induction. The stomach, jejunum, and ileum might have developed resistance to ischemia. The induction of VEGF may be beneficial in aging-associated impaired gastrointestinal homeostasis and neovascularization.