Multiple myeloma sekonder MPGN zemininde son dönem kronik böbrek yetmezliği


Yıldırım A., Dursun B., Yaşar M., Türk N. Ş., Yalçın N.

Pamukkale medical journal, vol.13, no.13, pp.431-434, 2020 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Case Report
  • Volume: 13 Issue: 13
  • Publication Date: 2020
  • Doi Number: 10.31362/patd.593968
  • Journal Name: Pamukkale medical journal
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.431-434
  • Dokuz Eylül University Affiliated: No

Abstract

Abstract

Membranoproliferative glomerulonephritis is an immune complex-mediated glomerulonephritis characterised by subendothelial and mesangial immun complex deposits. Monoclonal gammopathies are among the few known reasons for membranoproliferative glomerulonephritis. In this case, multiple myeloma is presented as a secondary cause of membranoproliferative glomerulonephritis leading to end stage renal failure. A 51 year old male was admitted with a long-standing history of uncontrolled hypertension, headache, pretibial edema. Laboratory analysis showed advanced kidney failure with marked hematuria. Kidney biopsy revealed membranoproliferative glomerulonephritis. The etiology of membranoproliferative glomerulonephritis was investigated. Urine immunofixation electrophoresis was consisted with free kappa light chain protein and multiple myeloma was diagnosed by bone marrow aspiration biopsy. This case points out to the importance of renal biopsy and further investigations to elucidate the underlying causes in patients with chronic renal failure of unknown cause and when membranoproliferative glomerulonephritis is diagnosed histopathologically, monoclonal gammopathies have to be considered as a secondary cause.