Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.28, sa.7, ss.332-338, 2000 (Scopus)
In this study, we compared the hepatocelluler toxic effects of isoflurane and sevoflurane by determining the plasma a GST levels in hemorrhagic shock model in rats. 18 male Wistar rats (251-363 g) were included in this study. Systemic arterial blood pressure of rats were invasively monitorised. Rats were randomly divided into three groups after hemorrhagic shock. During 30 minutes of hemorrhagic shock, all of the subjects were delivered either 0.7 MAC isoflurane + O2 (group 1, n=6), 0.7MAC sevoflurane + O2 (group S, n=6) or only O2 (group C, n=6) while breathing spontaneously. Liver functions were evaluated by measuring α-GST, AST, ALT and LDH levels obtained at times 2, 4, 24, and 48 hours of hemorrhagic shock in addition to baseline values. There was a statistically significant increase in plasma α-GST concentration the 2nd h in sevoflurane group, when compared to isoflurane and control groups. The 4th h, statistically significant increase in plasma α-GST concentration in isoflurane group when compared to sevoflurane group. Increase in plasma α-GST concentration the 48th h was statistically significant in isoflurane and in sevoflurane groups when compared to the control group. As a result we concluded that in rat hemorrhagic shock model when compared to the isoflurane and control groups sevoflurane causes hepatocellular injury at the 2nd h; isoflurane causes more significant injury than sevoflurane at the 4th h; both isoflurane and sevoflurane cause significant hepatocellular injury in comparison to the control group at the 48th h and regarding hepatocellular injury the difference between isoflurane and sevoflurane is not significant.