Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system

Aydin B., Guvenc G., Altinbas B., Niaz N., YALÇIN M.

NEUROPEPTIDES, vol.70, pp.9-15, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70
  • Publication Date: 2018
  • Doi Number: 10.1016/j.npep.2018.05.001
  • Journal Name: NEUROPEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9-15
  • Keywords: Nesfatin-1, Blood pressure, Heart rate, Posterior hypothalamic choline/acetylcholine, Cholinergic muscarinic and nicotinic receptors, THROMBOXANE A2 ANALOG, INJECTED CDP-CHOLINE, BLOOD-PRESSURE, HYPOTENSIVE RATS, CONSCIOUS RATS, SOLITARY TRACT, NEURONS, BRAIN, INVOLVEMENT, NUCLEUS
  • Dokuz Eylül University Affiliated: No


Nesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats.