Amnio-allantoic fluid exchange for the prevention of intestinal damage in gastroschisis III: Determination of the waste products removed by exchange

Aktug T., Ucan B., OLGUNER M., Akgur F., Ozer E., Caliskan S., ...Daha Fazla

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, cilt.8, sa.6, ss.326-328, 1998 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1055/s-2008-1071225
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.326-328
  • Anahtar Kelimeler: gastroschisis, fetal experiment
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Experimental amnio-allantoic fluid (AAF) exchange has been shown to prevent intestinal damage in the chicken embryo gastroschisis model. AAF contains both urinary and gastrointestinal waste products (UWP and GIWP). An experimental study was performed to find the waste products responsible for this intestinal damage. Gastroschisis was created in 20 chick embryos. Half were treated with AAF exchange, the other half were not treated. AAF samples were obtained for biochemical determination of urea nitrogen and creatinine as UWP, bile acids and bilirubin as GIWP at the end of the incubation. Intestines were evaluated by light microscopy, While GIWP (Bile salts and bilirubin) were significantly removed from AAF by exchange, the levels of UWP (urea nitrogen and creatinine) were unaffected, Intestinal wall thickness was less in the exchange group compared to the untreated group,