Vascular endothelial growth factor in gingival tissues and crevicular fluids of diabetic and healthy periodontal patients

Guneri P., Unlu F., Yesilbek B., Bayraktar F., Kokuludag A., HEKİMGİL M., ...More

JOURNAL OF PERIODONTOLOGY, vol.75, no.1, pp.91-97, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1902/jop.2004.75.1.91
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.91-97
  • Keywords: diabetes mellitus, gingival crevicular fluid/analysis, growth factors, vascular endothelial, periodontal diseases/etiology, HUMAN SALIVARY-GLANDS, PERMEABILITY FACTOR, FACTOR EXPRESSION, SERUM-LEVELS, FACTOR VEGF, ANGIOGENESIS, CELLS, RISK, LIPOPOLYSACCHARIDE, NEUTROPHILS
  • Dokuz Eylül University Affiliated: Yes


Background: Periodontal disease is one of the major oral problems encountered in patients with diabetes mellitus (DM). Vascular changes, neutrophil dysfunction, altered collagen synthesis, and genetic predisposition observed in DM may contribute to periodontitis; and the vascular alterations observed in such patients may depend on vascular endothelial growth factor (VEGF) actions. Few reports are available about the mechanism of neovascularization and the angiogenic factors that contribute to the periodontal pathology and the role of VEGF in periodontal diseases. The aim of this study is to compare VEGF expression in healthy and periodontally diseased tissues with gingival crevice fluid (GCF) of healthy persons and diabetic patients.