The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

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de Zwarte S. M. C., Brouwer R. M., Agartz I., Alda M., Aleman A., Alpert K. I., ...More

BIOLOGICAL PSYCHIATRY, vol.86, no.7, pp.545-556, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 86 Issue: 7
  • Publication Date: 2019
  • Doi Number: 10.1016/j.biopsych.2019.03.985
  • Journal Name: BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.545-556
  • Keywords: Bipolar disorder, Familial risk, Imaging, Meta-analysis, Neurodevelopment, Schizophrenia, GRAY-MATTER VOLUME, VOXEL-BASED MORPHOMETRY, HIGH GENETIC RISK, SOCIOECONOMIC-STATUS, SCHOOL PERFORMANCE, TWINS DISCORDANT, PREMORBID IQ, METAANALYSIS, CHILDHOOD, PREDISPOSITION
  • Dokuz Eylül University Affiliated: Yes

Abstract

BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.