Adherence to guideline-directed medical treatments in heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy
European Journal of Heart Failure, vol.27, no.12, pp.2716-2731, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 12
- Publication Date: 2025
- Doi Number: 10.1002/ejhf.70090
- Journal Name: European Journal of Heart Failure
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
- Page Numbers: pp.2716-2731
- Keywords: Heart failure, Adherence, Guidelines, Polypill, Fixed-dose combinations, Digital, Education, Multidisciplinary
- Dokuz Eylül University Affiliated: Yes
Abstract
Heart failure (HF) affects over 60 million individuals globally. Contemporary guideline-directed medical therapies (GDMT) reduce cardiovascular mortality and HF hospitalizations. However, medication non-adherence represents a critical barrier limiting real-world efficacy of GDMT. This scientific statement aims to provide a comprehensive framework for understanding, measuring, and addressing medication non-adherence in HF management across diverse healthcare settings. Addressing medication non-adherence requires systematic, multifaceted approaches targeting individual patient barriers while implementing system-level interventions. Polypills, digital monitoring platforms, enhanced patient education and empowerment, and multidisciplinary care models represent promising strategies to optimize therapeutic adherence and improve clinical outcomes in HF management.