Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism

EMREN, SADIK; EREN, NİHAN; ÖZYILDIRIM, Serhan; Bulbul, Hale; Uslu, SADETTİN

doi:10.5606/tgkdc.dergisi.2015.10141

Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism

EMREN S. V., EREN N. K., ÖZYILDIRIM S., Bulbul H., Uslu S.

TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.23, sa.1, ss.150-153, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 1
Basım Tarihi: 2015
Doi Numarası: 10.5606/tgkdc.dergisi.2015.10141
Dergi Adı: TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.150-153
Anahtar Kelimeler: Bleeding, gene polymorphism, warfarin, ANTICOAGULATION
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Warfarin is the most frequently used oral anticoagulant agent today. Warfarin response can be affected by environmental factors such as dietary habits and drugs as well as genetic factors, and this might increase bleeding risk. In this article, we report a 79-year-old male patient who developed nontraumatic hematoma of left lower extremity despite using low-dose warfarin, and whose genetic analyses revealed CYP2C9*2*3, VKORC1 AA and VKORC1 TT gene polymorphisms.