EVALUATION OF SECRETED FRIZZLED-RELATED PROTEIN-4 METHYLATION PROFILES IN PATIENTS WITH BCR/ABL POSITIVE CHRONIC MYELOID LEUKEMIA

Pehlivan M., Sirin N., ÖZSAN G. H., Yuce Z., SERCAN H. O.

WORLD CANCER RESEARCH JOURNAL, cilt.8, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2021
  • Dergi Adı: WORLD CANCER RESEARCH JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Anahtar Kelimeler: sFRP4, CML, DNA methylation, Wnt signaling, Cytogenetics, ANTAGONISTS, EXPRESSION, PATHWAY, FAMILY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the chromosomal translocation t(9;22) encoding for the Bcr/Abl fusion gene. Secreted Frizzled Related Protein (sFRP) gene products are antagonists of Wnt signaling and their epigenetic silencing has been reported in different types of leukemia. While epigenetic silencing has been extensively reported for sFRP, sFRP4 is a family member less studied. We aimed to study epigenetic silencing of sFRP4 in CML patients.