EVALUATION OF SECRETED FRIZZLED-RELATED PROTEIN-4 METHYLATION PROFILES IN PATIENTS WITH BCR/ABL POSITIVE CHRONIC MYELOID LEUKEMIA
WORLD CANCER RESEARCH JOURNAL, vol.8, 2021 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 8
- Publication Date: 2021
- Doi Number: 10.32113/wcrj_20215_1967
- Journal Name: WORLD CANCER RESEARCH JOURNAL
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Keywords: sFRP4, CML, DNA methylation, Wnt signaling, Cytogenetics, ANTAGONISTS, EXPRESSION, PATHWAY, FAMILY
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the chromosomal translocation t(9;22) encoding for the Bcr/Abl fusion gene. Secreted Frizzled Related Protein (sFRP) gene products are antagonists of Wnt signaling and their epigenetic silencing has been reported in different types of leukemia. While epigenetic silencing has been extensively reported for sFRP, sFRP4 is a family member less studied. We aimed to study epigenetic silencing of sFRP4 in CML patients.