Secondary Cancers

Cecen E., Bolaman Z.

UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, vol.20, no.3, pp.190-200, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 20 Issue: 3
  • Publication Date: 2010
  • Journal Name: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.190-200
  • Keywords: Secondary cancer, Second primary cancers, Multipl primary cancer, Late effects, 2ND MALIGNANT NEOPLASMS, ACUTE MYELOID-LEUKEMIA, ACUTE LYMPHOBLASTIC-LEUKEMIA, CHILDHOOD HODGKINS-DISEASE, LONG-TERM SURVIVORS, STEM-CELL TRANSPLANTATION, EXTENDED FOLLOW-UP, BREAST-CANCER, MYELODYSPLASTIC SYNDROME, ADOLESCENT CANCER
  • Dokuz Eylül University Affiliated: No

Abstract

Secondary cancer refers to a new primary cancer that is caused by previous cancer treatment, or a new primary cancer in a person with a history of cancer. Because of the improvement of diagnosis and treatment for childhood and adult cancers have improved over several decades, the proportion of cancer survivors within the general population increases every years. The prolongation of survival in increasing numbers of patients, identification and quantification of the late effects of cancer and its therapy have become critical. One of the most serious events experienced by cancer survivors is the diagnosis of a new cancer. Childhood and adult cancer survivors have an increased risk of developing second and subsequent cancers that varies by host factors (genetics, immune function, hormonal status); primary cancer therapy; environmental exposures; and lifestyle factors. An improved understanding of therapy-related second malignancies can guide alterations in regimens to minimize cytotoxic treatment exposure. Besides effective screening methods and preventive strategies should be developed to risk for second primary cancers.