Akademik Veri Yönetim Sistemi
5. Ulusal Kristalografi Toplantısı, Samsun, Türkiye, 17 - 19 Mayıs 2024, ss.1-3
Colorful fruits and vegetables have been linked to improved health and lifespan, as well as a lower risk of some chronic diseases. Many studies have focused on the properties of polyphenolic chemicals, a wide family of compounds found in plants. Inside this family, flavonoids are abundant in foods like fruits and vegetables. The most prominent class of flavonoids is anthocyanins. Anthocyanins have received significant attention in pharmaceutical research due to their vibrant color, excellent water solubility, and beneficial biological effects. In their glycoside form, which is bound to sugar molecules, is more stable and less sensitive to degradation caused by light, pH changes, and heat. In this presentation, the biological activity and the potential inhibition properties of malvin (malvidin-3,5-diglucoside) molecule on SARS-CoV-2 protein will be discussed in detail. The results of the theoretical studies such as the geometry of the molecule, its electronic structure, and vibrational and topological analysis will be shown. Also, the outcomes of inhibition studies and biological activity predictions that are carried out by Molecular Docking and ADME will be given, and compared to one of the most effective drugs that has been used during the Covid-19 pandemic.