Akademik Veri Yönetim Sistemi
2025 SIRS conference, Illinois, Amerika Birleşik Devletleri, 29 Mart - 02 Nisan 2025, ss.120, (Özet Bildiri)
Background: White matter microstructure abnormalities are commonly observed in individuals diagnosed with psychosis, including schizophrenia. This study aimed to investigate differences in fractional anisotropy (FA) measures between individuals with first
episode psychosis (FEP), those at ultra-high risk for psychosis (UHR-P), and those at familial high risk for psychosis (FHR-P).
Methods: Thirty individuals with FEP, 31 individuals with UHR-P, 18 individuals with FHR-P, and 19 HCs participated in this study. Participants underwent a comprehensive clinical interview and MRI scanning, with diffusion-tensor imaging (DTI) acquired on a 3T MRI scanner to measure fractional anisotropy (FA). Diffusion data were analyzed using FSL’s Tract-Based Spatial Statistics (TBSS). Group comparisons were conducted using the randomise tool with 5.000 permutations, applying threshold-free cluster enhancement (TFCE) to correct for multiple comparisons. Statistical significance was set at p < 0.05. Age and gender were included as covariates in all analyses.
Results: Compared to healthy controls, individuals with FEP and FHR-P showed decreased FA values in the superior longitudinal fasciculus in both hemispheres. Additionally, the FHR-P group exhibited lower FA values in the left superior longitudinal fasciculus compared to the UHR-P group.
Discussion: These findings suggest that the integrity of white matter fibers is disrupted in individuals with early psychosis and those at risk for developing this mental disorder. Further studies with larger samples, incorporating changes in structural connectivity within these populations, may provide a better understanding of the neurobiology of psychosis