Effect of subminimal inhibitory concentrations of gentamicin, penicillin, trimethoprim-sulfamethoxazole on adherence of uropathogenic Escherichia coli strains.
Journal of chemotherapy (Florence, Italy), cilt.14, sa.2, ss.161-5, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2002
- Doi Numarası: 10.1179/joc.2002.14.2.161
- Dergi Adı: Journal of chemotherapy (Florence, Italy)
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.161-5
- Anahtar Kelimeler: sub MIC, Escherichia coli, adherence, gentamicin, penicillin, trimethoprim-sulfamethoxazole, urinary tract infections
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Evaluating the adherence factor of uropathogenic Escherichia coli is important for assessing the relative efficiency of antimicrobials when used at subminimal inhibitory concentration (sub-MICs). The microdilution method was used to determine the MICs of gentamicin, trimethoprim-sulfamethaxozole and penicillin. Then the efficacy of antimicrobial sub-MICs was determined by hemagglutination and adherence assays. Instead of showing nearly the same MICs, gentamicin had nearly twice the activity of trimethoprim-sulfamethaxozole. Gentamicin, as a "long acting" agent, can be accepted as being more effective than trimethoprim-sulfamethaxozole or penicillin, especially at sub-MICs, against adherence factors of uropathogenic E. coli, and can be used as monotherapy for urinary tract infections.