Effect of subminimal inhibitory concentrations of gentamicin, penicillin, trimethoprim-sulfamethoxazole on adherence of uropathogenic Escherichia coli strains.

BASKIN A. H., Dogan Y., Bahar I., Yulug N.

Journal of chemotherapy (Florence, Italy), vol.14, no.2, pp.161-5, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1179/joc.2002.14.2.161
  • Journal Name: Journal of chemotherapy (Florence, Italy)
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.161-5
  • Keywords: sub MIC, Escherichia coli, adherence, gentamicin, penicillin, trimethoprim-sulfamethoxazole, urinary tract infections, HEMAGGLUTINATION, COLONIZATION, ANTIBIOTICS, INFECTIONS, ABSENCE, MANNOSE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Evaluating the adherence factor of uropathogenic Escherichia coli is important for assessing the relative efficiency of antimicrobials when used at subminimal inhibitory concentration (sub-MICs). The microdilution method was used to determine the MICs of gentamicin, trimethoprim-sulfamethaxozole and penicillin. Then the efficacy of antimicrobial sub-MICs was determined by hemagglutination and adherence assays. Instead of showing nearly the same MICs, gentamicin had nearly twice the activity of trimethoprim-sulfamethaxozole. Gentamicin, as a "long acting" agent, can be accepted as being more effective than trimethoprim-sulfamethaxozole or penicillin, especially at sub-MICs, against adherence factors of uropathogenic E. coli, and can be used as monotherapy for urinary tract infections.