Effect of subminimal inhibitory concentrations of gentamicin, penicillin, trimethoprim-sulfamethoxazole on adherence of uropathogenic Escherichia coli strains.

BASKIN A. H., Dogan Y., Bahar I., Yulug N.

Journal of chemotherapy (Florence, Italy), cilt.14, sa.2, ss.161-5, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1179/joc.2002.14.2.161
  • Dergi Adı: Journal of chemotherapy (Florence, Italy)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.161-5
  • Anahtar Kelimeler: sub MIC, Escherichia coli, adherence, gentamicin, penicillin, trimethoprim-sulfamethoxazole, urinary tract infections, HEMAGGLUTINATION, COLONIZATION, ANTIBIOTICS, INFECTIONS, ABSENCE, MANNOSE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Evaluating the adherence factor of uropathogenic Escherichia coli is important for assessing the relative efficiency of antimicrobials when used at subminimal inhibitory concentration (sub-MICs). The microdilution method was used to determine the MICs of gentamicin, trimethoprim-sulfamethaxozole and penicillin. Then the efficacy of antimicrobial sub-MICs was determined by hemagglutination and adherence assays. Instead of showing nearly the same MICs, gentamicin had nearly twice the activity of trimethoprim-sulfamethaxozole. Gentamicin, as a "long acting" agent, can be accepted as being more effective than trimethoprim-sulfamethaxozole or penicillin, especially at sub-MICs, against adherence factors of uropathogenic E. coli, and can be used as monotherapy for urinary tract infections.