Abnormal white matter integrity as a structural endophenotype for bipolar disorder
PSYCHOLOGICAL MEDICINE, vol.46, no.7, pp.1547-1558, 2016 (SCI-Expanded, SSCI, Scopus)
- Publication Type: Article / Article
- Volume: 46 Issue: 7
- Publication Date: 2016
- Doi Number: 10.1017/s0033291716000180
- Journal Name: PSYCHOLOGICAL MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Page Numbers: pp.1547-1558
- Keywords: Bipolar disorder, diffusion tensor imaging, endophenotypes, fractional anisotropy, siblings, white matter
- Dokuz Eylül University Affiliated: Yes
Abstract
Background. Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls.