Abnormal white matter integrity as a structural endophenotype for bipolar disorder

Saricicek A., Zorlu N., Yalin N., Hidiroglu C., Cavusoglu B., Ceylan D., ...More

PSYCHOLOGICAL MEDICINE, vol.46, no.7, pp.1547-1558, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1017/s0033291716000180
  • Journal Name: PSYCHOLOGICAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.1547-1558
  • Keywords: Bipolar disorder, diffusion tensor imaging, endophenotypes, fractional anisotropy, siblings, white matter, MICROSTRUCTURAL ABNORMALITIES, SPATIAL STATISTICS, PREFRONTAL CORTEX, MOOD DISORDERS, I DISORDER, ANATOMICAL CONNECTIVITY, UNAFFECTED RELATIVES, UNIPOLAR DEPRESSION, GENETIC RISK, SCHIZOPHRENIA
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls.