Which prognostic marker is responsible for the clinical heterogeneity in CLL with 13q deletion?

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DURAK ARAS B., IŞIK S., ÜSKÜDAR TEKE H., Aslan A., Yavasoglu F., Gulbas Z., ...More

MOLECULAR CYTOGENETICS, vol.14, no.1, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1186/s13039-020-00522-1
  • Journal Name: MOLECULAR CYTOGENETICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Keywords: B-CLL, FISH, Prognostic marker, RB1 deletions, 13q deletions
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Deletion of 13q14 [del(13q)] is the most common cytogenetic change (50%) in chronic lymphoblastic leukemia (CLL), and it is a good prognostic factor if it is detected as a sole aberration by FISH. However, it is observed the clinical course of CLL cases with del(13q) are quite heterogeneous and the responsible for this clinical heterogeneity has not been established yet. Some investigators suggest type II deletion (include RB1 gene) is associated with more aggressive clinical course. Also, it is suggested that the deletion burden and the deletion type have a prognostic effect. In this study, we aimed to investigate the effect of RB1 gene deletion, deletion burden and deletion type on overall survival (OS), disease stage and time to first treatment (TTFT) in patients with isolated del(3q). Sixty eight cases, detected isolated del(13q) were included in the study. Also, RB1 deletion was analyzed from peripheral blood of them using FISH.