The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder

Ekmekci S., Kucuk U., Kaya O., YÖRÜKOĞLU K.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, vol.67, no.1, pp.64-70, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1590/1806-9282.67.01.20200297
  • Journal Name: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.64-70
  • Keywords: Urinary bladder neoplasms, Microsatellite instability, Young adult, Carcinoma, LYNCH SYNDROME, CANCER, EXPRESSION, MUTATION, PREDICTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinoma seen in patients under 40 years of age and tumor microsatellite instability status using immunohistochemistry.