Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

GÜNGÖR B., Yagci F. C., Gursel I., Gursel M.

ONCOIMMUNOLOGY, vol.3, no.7, 2014 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 3 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.4161/21624011.2014.950166
  • Journal Name: ONCOIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: CpG ODN, Type I interferon, vaccine adjuvant
  • Dokuz Eylül University Affiliated: No

Abstract

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.