Oxidative Stress and Adenosine Deaminase Activity in Sheep with Pulmonary Adenocarcinoma

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Kiziltepe S., Karakurt E., Eser G., Coskun N., Gunes S., OKULMUŞ Ç., ...Daha Fazla

ACTA VETERINARIA-BEOGRAD, cilt.76, sa.1, ss.66-87, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 1
  • Basım Tarihi: 2026
  • Doi Numarası: 10.2478/acve-2026-0005
  • Dergi Adı: ACTA VETERINARIA-BEOGRAD
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Central & Eastern European Academic Source (CEEAS), EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.66-87
  • Anahtar Kelimeler: Pulmonary Adenocarcinoma, Oxidative Stress, Adenosine Deaminase, Sheep
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Ovine pulmonary adenocarcinoma (OPA) is an infectious and neoplastic disease etiologically linked to the Jaagsiekte sheep retrovirus (JSRV), characterised by tumour lesions of the lung. Because of the economic losses it induces, OPA is of great importance for flock health. In this study, oxidative stress markers and adenosine deaminase (ADA) activity were quantified in lung tissue from sheep, both healthy and those naturally afflicted with OPA. Compared to healthy sheep, malondialdehyde (MDA), nitric oxide (NO), ceruloplasmin (CP) and ADA concentrations/activities were significantly increased (P<0.05 and P<0.001) in fresh lung tissues from JSRV-infected sheep, while reduced glutathione (GSH) levels were significantly decreased (P<0.05). In conclusion, pronounced oxidative stress and increased ADA enzyme activity were detected in the JSRV-infected sheep. These findings suggest that ADA activity could serve as a biomarker for disease diagnosis.