Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections.

Aydin, M.; Ergonul, O.; Azap, A.; Bilgin, H.; Aydin, G.; Cavus, SEMA; Demiroglu, Y.; Aliskan, H.; Memikoglu, O.; Menekse, S.; Kaya, S.; Demir, N.; Karaoglan, I.; Basaran, S.; Hatipoglu, C.; Erdinc, S.; Yilmaz, E.; Tumturk, A.; Tezer, Y.; Demirkaya, H.; Cakar, S.; Keske, S.; Tekin, S.; Yardimci, C.; Karakoc, C.; Ergen, P.; Azap, O.; DURMUŞOĞLU, LÜTFİYE; Ural, O.; Can, F.; Akalin, H.

doi:10.1016/j.jhin.2017.11.014

Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections.

Aydin M., Ergonul O., Azap A., Bilgin H., Aydin G., Cavus S., ...More

The Journal of hospital infection, vol.98, no.3, pp.260-263, 2018 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 98 Issue: 3
Publication Date: 2018
Doi Number: 10.1016/j.jhin.2017.11.014
Journal Name: The Journal of hospital infection
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.260-263
Keywords: Bloodstream, Gram-negative, Health care, Colistin MIC
Dokuz Eylül University Affiliated: Yes

Abstract

This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality. (C) 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.