Neutrophil-to-Lymphocyte Ratio: Could it be used in the clinic as Prognostic Marker for Gastrointestinal Stromal Tumor?

ATİLA K., Arslan N. C., Derici S., Canda A. E., SAĞOL Ö., ÖZTOP İ., ...Daha Fazla

HEPATO-GASTROENTEROLOGY, cilt.61, sa.134, ss.1649-1653, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 134
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5754/hge14056
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1649-1653
  • Anahtar Kelimeler: Neutrophil-to-lymphocyte ratio, gastrointestinal stromal tumor, prognostic marker, survival, PERIPHERAL-BLOOD GRANULOCYTES, NASOPHARYNGEAL CARCINOMA, HEPATOCELLULAR-CARCINOMA, PREOPERATIVE NEUTROPHIL, CANCER, INHIBITION, DIAGNOSIS, RESECTION, SURVIVAL
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: The association between systemic inflammatory response and tumor biology has been well documented over the last decade. The aim of this study is to investigate the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in gastrointestinal stromal tumors (GISTs). Methodology: A prospectively recorded database of 67 patients who underwent surgical resection for GIST was reviewed. High and low NLR were defined with respect to the sample median, which was 1.92. Demographical, clinicopathological, and surgical characteristics were analyzed as well as disease free survival (DFS) rates according to NLR classification. Results: We observed better disease free survival rates in patients with low NLR compared to patients with high NLR (85.7% and 69%, respectively; p=0.037). Estimated five-year overall and disease free survival rates were, 95.1% and 78.7%, respectively In univariate analysis synchronous sarcomatosis, tumor size, mitotic rate, presence of necrosis, lymph node metastasis, surgical margin status, risk category and NLR were associated with DFS. On multivariate analysis sarcomatosis (HR: 30.455), surgical margin status (HR: 4.228) and necrosis (HR: 4.415) were found as independent prognostic factors for DFS. Conclusion: NLR can give information, about inflammatory status, tumor aggressivity and prognosis in GIST patients. It could be a new prognostic factor for GIST patients.