Comparison of the Effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats

Dogan G., Dogan G., Kayir S., YAĞAN Ö., HANCI V.

JOURNAL OF SURGICAL RESEARCH, vol.248, pp.123-128, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 248
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jss.2019.12.006
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.123-128
  • Keywords: Sugammadex, Bursting pressure, Neostigmine, Hydroxyproline, INTESTINAL ANASTOMOSES, LEAKAGE, REVERSAL, SEPSIS, MODEL
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: After colorectal surgery, anastomotic leakage is a major cause of mortality and morbidity. There are many factors affecting anastomotic leakage. It is known that agents such as neostigmine that is used to reverse neuromuscular blockade have certain effects on anastomosis. In our study, in which we planned to test this hypothesis, we aimed to compare the possible effects of different doses of sugammadex and neostigmine on colon anastomosis strength in a colonic resection anastomosis model in rats.