Comparison of the Effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats

Dogan G., Dogan G., Kayir S., YAĞAN Ö., HANCI V.

JOURNAL OF SURGICAL RESEARCH, cilt.248, ss.123-128, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 248
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jss.2019.12.006
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.123-128
  • Anahtar Kelimeler: Sugammadex, Bursting pressure, Neostigmine, Hydroxyproline, INTESTINAL ANASTOMOSES, LEAKAGE, REVERSAL, SEPSIS, MODEL
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: After colorectal surgery, anastomotic leakage is a major cause of mortality and morbidity. There are many factors affecting anastomotic leakage. It is known that agents such as neostigmine that is used to reverse neuromuscular blockade have certain effects on anastomosis. In our study, in which we planned to test this hypothesis, we aimed to compare the possible effects of different doses of sugammadex and neostigmine on colon anastomosis strength in a colonic resection anastomosis model in rats.