The objective of this study was to improve the performance of flexible pavement through suitable aggregate gradation. Thus, initially, the dynamic modulus of asphalt mixtures |E*| for different aggregate gradations were predicted, and suitable aggregate gradation was determined. Then the performance of three different pavement structures for two aggregate gradations (Mid and Suitable), using AASHTOWare Pavement ME Design 2.5. 5, were evaluated for local conditions of Izmir, Turkey. The analysis result revealed that using suitable values compared to middle values increased the |E*| and improved the rutting and fatigue resistance of all pavement structures for any traffic levels. The output of this study can be used as a guide for hot mixed asphalt mix design and pavement design based on Mechanistic-Empirical Pavement Design Guide as well.