Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders

de Albuquerque J. B., Mueller C., GÜNGÖR B.

CELLS, vol.10, no.8, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.3390/cells10081882
  • Journal Name: CELLS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
  • Keywords: tissue-resident T cells, T cell retention, circulating T cells, memory T cells, intestinal inflammation
  • Dokuz Eylül University Affiliated: No

Abstract

Tissue-resident memory T (T-RM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of T-RM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, T-RM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis, celiac disease and inflammatory bowel diseases. In this review, we focus on current concepts of T-RM cell biology, particularly in the intestine, and discuss recent findings on their involvement in chronic relapsing-remitting inflammatory disorders. Potential therapeutic strategies to interfere with these T-RM cell-mediated immunopathologies are discussed.