Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an immunocompetent Chinese elderly woman

Wan Y., He D., Ye Y., Zhang W., Zhao S., Long Y., ...Daha Fazla

CARDIOVASCULAR PATHOLOGY, cilt.31, ss.54-56, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.carpath.2017.07.006
  • Dergi Adı: CARDIOVASCULAR PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.54-56
  • Anahtar Kelimeler: Cardiac lymphoma, Diffuse large B-cell lymphoma, Double-expressor lymphoma, RITUXIMAB PLUS CYCLOPHOSPHAMIDE, STRONG PREDICTOR, CLASSIFICATION, VINCRISTINE, DOXORUBICIN, PREDNISONE, T(14/18), HEART
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Primary cardiac lymphoma is a rare type of extranodal lymphoma that involves only heart and/or pericardium. It is usually observed in immunodeficient people. However, immunocompetent patients may also suffer from this disease. Most primary cardiac lymphomas are of B-cell lineage, and they usually present as diffuse large B-cell lymphoma (DLBCL). Diffuse large B-cell lymphoma with concurrently high MYC and BCL2 expression, which is named as double-expressor lymphoma (DEL), is a rare subtype of DLBCL. Herewe report a rare case of a primary cardiac DEL in an immunocompetent 65-year old Chinese woman. Echocardiography and magnetic resonance imaging revealed a mass of 6.6 cmx5.6 cm in the right atrium. No tumor formations were observed in other organs. Histopathologic examination showed that the cardiac tumor was diffuse large B-cell lymphoma, nongerminal center B-cell type by Hans algorithm. The tumor cells showed high MYC and BCL2 protein expression by immunohistochemistry, with high proliferative index. (C) 2017 Elsevier Inc. All rights reserved.