Immunohistological examination of thyroid hormone receptor expressions in placenta in maternal hypothyroidism
Journal of Experimental and Clinical Medicine (Turkey), vol.42, no.2, pp.143-145, 2025 (Scopus)
- Publication Type: Article / Article
- Volume: 42 Issue: 2
- Publication Date: 2025
- Doi Number: 10.52142/omujecm.42.2.8
- Journal Name: Journal of Experimental and Clinical Medicine (Turkey)
- Journal Indexes: Scopus, Academic Search Premier
- Page Numbers: pp.143-145
- Keywords: maternal hypothyroidism, placenta, thyroid hormone receptors
- Dokuz Eylül University Affiliated: Yes
Abstract
Thyroid hormones are necessary for the development of a healthy fetus and placenta. In our study, we evaluated the thyroid hormone receptor expressions in the placentas of pregnant women with hypothyroidism. We evaluated term placentas in two groups: control (n=5) and hypothyroidism (n=5). THRα and THRß were expressed in the placenta, especially in syncytiotrophoblasts, and also in placental macrophages. THRα expression was decreased in the hypothyroid group compared to the control group, but it was statistically non-significant (p=0,850). THRß expression was decreased in the hypothyroid group compared to the control group at a statistically significant level (p=0,004). The results showed that thyroid hormone receptors are associated with maternal hypothyroidism.