The relationship between the education level of male patients with LUTS and IPSS
3rd EAU Baltic Meeting, Tallinn, Estonia, 27 - 28 May 2016, vol.15, pp.1237, (Summary Text)
- Publication Type: Conference Paper / Summary Text
- Volume: 15
- Doi Number: 10.1016/s1569-9056(16)15064-x
- City: Tallinn
- Country: Estonia
- Page Numbers: pp.1237
- Dokuz Eylül University Affiliated: Yes
Abstract
Understanding the role of microenvironment in cancer growth and metastasis is a key issue for cancer research. Here, we study the effect of osmotic pressure on the functional properties of primary and metastatic melanoma cell lines. In particular, we experimentally quantify individual cell motility and transmigration capability. We then perform a circular scratch assay to study how a cancer cell front invades an empty space. Our results show that primary melanoma cells are sensitive to a low osmotic pressure, while metastatic cells are less. To better understand the experimental results, we introduce and study a continuous model for the dynamics of a cell layer and a stochastic discrete model for cell proliferation and diffusion. The two models capture essential features of the experimental results and allow to make predictions for a wide range of experimentally measurable parameters.