The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status

Akman T., ÖZTOP İ., BAŞBINAR Y., ÜNEK İ. T., DEMİR N., ELLİDOKUZ H., ...More

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.12, no.1, pp.96-102, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.4103/0973-1482.148684
  • Journal Name: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.96-102
  • Keywords: Clinicopathological properties, KRAS, metastatic colorectal cancer, prognosis
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: KRAS mutations have a significant role in the consecutive activation of RAS-RAF-MEK-ERK pathway in colorectal cancer. Approximately 30-35% of sporadic colorectal cancers have KRAS mutation. While the predictive role of KRAS is commonly accepted at the present time, its prognostic role and association with different clinical and histopathological properties are currently unclear and inconsistent. The intent of this study, has been to evaluate the associations between KRAS gene mutations and clinicopathological features and survival times in Turkish colorectal cancer patients.