The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status

Akman T., ÖZTOP İ., BAŞBINAR Y., ÜNEK İ. T., DEMİR N., ELLİDOKUZ H., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.12, sa.1, ss.96-102, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4103/0973-1482.148684
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-102
  • Anahtar Kelimeler: Clinicopathological properties, KRAS, metastatic colorectal cancer, prognosis, K-RAS MUTATIONS, CELL LUNG-CANCER, III COLON-CANCER, 1ST-LINE TREATMENT, PROGNOSTIC-FACTOR, GENE-EXPRESSION, LIFE-STYLE, STAGE-II, B-RAF, CETUXIMAB
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: KRAS mutations have a significant role in the consecutive activation of RAS-RAF-MEK-ERK pathway in colorectal cancer. Approximately 30-35% of sporadic colorectal cancers have KRAS mutation. While the predictive role of KRAS is commonly accepted at the present time, its prognostic role and association with different clinical and histopathological properties are currently unclear and inconsistent. The intent of this study, has been to evaluate the associations between KRAS gene mutations and clinicopathological features and survival times in Turkish colorectal cancer patients.