Asymmetric transfer hydrogenation reaction in water: Comparison of chiral proline amide/amine ruthenium(II) complexes

DENİZALTI S., Mercan D., Sen B., Gokce A. G., Cetinkaya B.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol.779, pp.62-66, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 779
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jorganchem.2014.12.023
  • Journal Name: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-66
  • Keywords: L-proline, Ruthenium, Asymmetric transfer hydrogenation
  • Dokuz Eylül University Affiliated: Yes

Abstract

Chiral proline amide/amine ligands (2, 3), synthesized by multi-step reaction starting from L-proline (1), were evaluated as catalyst generated in situ from [RuCl2(p-cymene)](2) for asymmetric transfer hydrogenation of aromatic ketones in the presence of sodium formiate and sodium dodecyl sulfate (SDS). The results revealed that efficiencies and enantioselectivities strongly depend on the N-substituents. (C) 2014 Elsevier B.V. All rights reserved.