The cell based dressing with living allogenic keratinocytes in the treatment of foot ulcers: a case study

Bayram Y., Deveci M., Imirzalioglu N., Soysal Y., Sengezer M.

BRITISH JOURNAL OF PLASTIC SURGERY, vol.58, no.7, pp.988-996, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.1016/j.bjps.2005.04.031
  • Journal Name: BRITISH JOURNAL OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.988-996
  • Keywords: cultured keratinocyte, diabetic wound, diabetic foot, wound healing, AUTOLOGOUS KERATINOCYTES, SKIN, ACID
  • Dokuz Eylül University Affiliated: No

Abstract

In this study, we aimed to investigate the efficacy of cell based dressing with living allogenic keratinocytes in diabetic foot patients. To address this issue, the cultured keratinocytes were attached to the microcarriers produced from polyethylene and silica. The microcarriers were then applied to the wounds at 3-day intervals. Forty patients with grade II and III diabetic foot ulcers were included into the study. The patients were randomised into two groups (n = 20). The treatment and control groups received cell based dressing and microcarriers kept in culture medium overnight, respectively. The wound size was recorded at 3 days intervals. The wounds were also categorised by a specific scoring system considering the wound contraction, granulation tissue formation, epithetisation and discharge from the wounds. The high score indicates better condition.