Sequential multiagent antioxidant therapy has no synergistic scavenging effect on hepatocytes

SÖKMEN S., Mentes A., Mutaf I., Bayindir O., YILMAZ BARBET F., Yuce G.

European Congress of the International-Hepato-Pancreato-Biliary-Association (HAMBURG 97), Hamburg, Germany, 8 - 12 June 1997, pp.83-87 identifier

  • Publication Type: Conference Paper / Full Text
  • City: Hamburg
  • Country: Germany
  • Page Numbers: pp.83-87
  • Dokuz Eylül University Affiliated: Yes

Abstract

Oxygen free radicals (OFR) are potential mediators in the pathogenesis of tissue injury following ischemia - reperfusion (I/R) events. Therapies based on various physiological and pharmacological approaches have been explored to limit the detrimental consequences of I/R hepatocellular injury, In this experimental study, we have explored the scavenging effects of Mannitol 20 %, Verapamil, SOD and a combination of the latter two, to understand whether any regimen could give. further protection to the liver after the I/R insult. Although every regimen decreased hepatic damage compared to untreated controls, neither one suggested superiority against another.