Significance of tissue laminin P(1) elastase and fibronectin levels in transitional cell carcinoma of the bladder.

Kirkali G., Tuzel E., Guler C., Gezer S., Kirkali Z.

European urology, vol.39, no.3, pp.292-9, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1159/000052456
  • Journal Name: European urology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.292-9
  • Keywords: bladder, transitional cell carcinoma, laminin P-1, fibronectin, elastase, prognostic markers, CANCER, TUMORS, LINES, LOCALIZATION, EXPRESSION, METASTASIS, ONCOFETAL, INVASION, DISEASE, THERAPY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Elastase is a serine protease which hydrolyses connective tissue components. Laminin and fibronectin also play an important role in progression and invasion of cancer. The purpose of this study is to investigate the relation between tissue elastase, laminin P-1 and fibronectin levels and tumor characteristics, and analyze the potential of these as prognostic factors in transitional cell carcinoma (TCC) of the bladder.