In Vitro Biocompatibility and Antibacterial Activity of Electrospun Ag Doped HAp/PHBV Composite Nanofibers


Suslu A., ZİYLAN A., BAYIR E., Urkmez A. S., CÖCEN Ü.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.64, no.9, pp.465-473, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.1080/00914037.2014.977892
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.465-473
  • Keywords: Antibacterial, electrospinning, hydroxyapatite, nanofiber, PHBV, ANTIMICROBIAL PROPERTIES, SILVER, HYDROXYAPATITE, SCAFFOLDS, PROLIFERATION, FABRICATION, ADHESION, RELEASE
  • Dokuz Eylül University Affiliated: Yes

Abstract

The authors report herein in vitro antibacterial property and osteoblast biocompatibility of electrospun Ag doped HAp/PHBV (Ag-HAp/PHBV) composite nanofibers as an osteoconductive and antibacterial material for bone tissue engineering applications. Ag-HAp powders were synthesized and stable composite suspensions of Ag-HAp/PHBV were prepared with the aid of a cationic surfactant DTAB for the electrospinning process. Continuous and uniform composite nanofibers were generated within a diameter range of 400-900 nm. Obtained nanocomposite scaffolds provide a favorable environment for bonemineralization, SaOS-2 osteoblastic cell attachment and growth as well as they present antibacterial activity against E. coli and S. aureus bacteria without any noticeable cytotoxic effect.