Akademik Veri Yönetim Sistemi
2005 North American Congress of Clinical Toxicology Annual Meeting, Florida, Amerika Birleşik Devletleri, 9 - 14 Eylül 2005, cilt.43, sa.1, ss.772
Background: Poisonings concerning antidepressants that were reported to Drug and Poison Information Center (DPIC), in Izmir
between 1993 and 2004 was analyzed in our retrospective study. Methods: Age, sex, antidepressant type, route and reason for
the exposure, clinical effects and outcome of the poisoned patients were recorded on standart data forms, then entered into a
computerized database program. The severity of clinical manifestations were graded and assessed according to the EAPCCT/
IPCS Poisoning Severity Score. Statistical analysis was performed by using the chi-squre test. Result: The DPIC recorded 55,
962 calls concerning poisoning, 5,516 (9.9%) of them with 5857 antidepressant agents were antidepressant poisonings. Female/
male ratio was 2.7. The most involved antidepressants were tricyclics (62.4%, 45% of them amitripyline) and selective serotonin
re-uptake inhibitors (23.2%). The incidence of concomitant drug or alcohol intake with an antidepressant drug was 6.2%. While
accidental poisonings were the most common cause of poisoning between 0–6 years (92.1%), rate of intentional poisonings
were higher in 19–29 age group of adults (p<0.05) and 13–18 age group of children (p<0.0001). At the time of the telephone
inquiry, there were no symptoms in 80.6% of patients. Clinical effects were graded as mild (11.7%), moderate (2.6%) or severe
(5.1%). Observation alone was recommended in 23.9 of cases. Gastric lavage (0.8%), activated charcoal (31.2%), gastric lavage
with activated charcoal (30.6%) were other recommended gastrointestinal decontamination attempts. Outcome results of most of
the patients were not reached (85.7%). According to our results, only one 2.5 year old child died from amitriptyline
ingestion. Conclusion: Intentional poisonings with tricyclic antidepressant ingestions are common cause of antidepressant
poisonings reported to our DPIC. Although our center helps the appropriate management of antidepressant ingestions, spontan
reporting system limits the records of all antidepressant poisonings with their outcome results.