Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome

Uzel H., ÖZPELİT E., BADAK Ö., AKDENİZ B., BARIŞ N., Aytemiz F., ...More

ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY, vol.14, no.2, pp.134-139, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.5152/akd.2014.4433
  • Journal Name: ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.134-139
  • Keywords: clopidogrel resistance, acute coronary syndrome, mean platelet volume, diagnostic value, sensitivity, specificity, ACUTE MYOCARDIAL-INFARCTION, ST-SEGMENT ELEVATION, CONTROLLED TRIAL, RISK-FACTOR, ASPIRIN, THERAPY, AGGREGATION, INTERVENTION, REACTIVITY, THROMBOSIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Clopidogrel therapy is the standard of care in patients with acute coronary syndrome (ACS) and stent implantation. However, concern arises because 25% of subjects are nonresponders to clopidogrel. As this nonresponsiveness is associated with increased adverse outcome, detection of these subjects in daily practice is important in order to withhold a more aggressive therapy and closer follow up. In this study we aimed to evaluate the relation between mean platelet volume (MPV) which is an indicator of platelet activation and clopidogrel nonresponsiveness.