Effects of dextran and pentoxifylline on hemorrhagic shock-induced P-selectin expression

Akgur F., Zibari G., McDonald J., Granger D., Brown M.

JOURNAL OF SURGICAL RESEARCH, cilt.87, sa.2, ss.232-238, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1006/jsre.1999.5758
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.232-238
  • Anahtar Kelimeler: cell adhesion molecule, ischemia, reperfusion, hemorrhagic shock, leukocyte, dextran, pentoxifylline
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background. Dextran and pentoxifylline have been shown to prevent leukocyte-endothelium adherence encountered after hemorrhagic shock, P-Selectin is the first endothelial cell adhesion molecule to be upregulated after an ischemic insult. We investigated the effects of resuscitation with dextran 70 and administration of pentoifylline during resuscitation on hemorrhagic shock-induced P-selectin expression.