Effects of dextran and pentoxifylline on hemorrhagic shock-induced P-selectin expression

Akgur F., Zibari G., McDonald J., Granger D., Brown M.

JOURNAL OF SURGICAL RESEARCH, vol.87, no.2, pp.232-238, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1006/jsre.1999.5758
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-238
  • Keywords: cell adhesion molecule, ischemia, reperfusion, hemorrhagic shock, leukocyte, dextran, pentoxifylline, ENDOTHELIAL CELL-INTERACTIONS, MICROVASCULAR BLOOD-FLOW, REPERFUSION INJURY, HYPERTONIC SALINE, CRYSTALLOID RESUSCITATION, MOLECULAR MECHANISMS, FLUID RESUSCITATION, TISSUE-INJURY, IN-VIVO, RATS
  • Dokuz Eylül University Affiliated: No

Abstract

Background. Dextran and pentoxifylline have been shown to prevent leukocyte-endothelium adherence encountered after hemorrhagic shock, P-Selectin is the first endothelial cell adhesion molecule to be upregulated after an ischemic insult. We investigated the effects of resuscitation with dextran 70 and administration of pentoifylline during resuscitation on hemorrhagic shock-induced P-selectin expression.