An Exceptional Etiology of a Rare Disease: Pneumatosis Intestinalis in the Intensive Care Unit due to Chronic Graft-Versus-Host Disease

Creative Commons License

ÇALIŞKAN T., ÖZKÖK H., KÜÇÜK M., Erdogan B. T., Uygun V., SAVRAN Y., ...More

TURKISH JOURNAL OF INTENSIVE CARE-TURK YOGUN BAKIM DERGISI, vol.19, no.4, pp.200-204, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.4274/tybd.galenos.2021.55265
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.200-204
  • Keywords: Chronic graft versus host disease, pneumatosis intestinalis, intensive care, CONSENSUS DEVELOPMENT PROJECT, CYSTOIDES-INTESTINALIS, CLINICAL-TRIALS, PATHOGENESIS, DIAGNOSIS, CRITERIA, AIR
  • Dokuz Eylül University Affiliated: Yes


Pneumatosis intestinalis (PI) is a rare disease, which presents a wide range of and mechanical procedures, gave rise to this complication. Abdominal computerized tomography is the preferred diagnostic tool with high sensitivity. The diagnosis depends on free air detection in the intramural portion of the gastrointestinal system and main and intrahepatic branches of the portal venous structures. However, the exact mechanism is unknown. The clinical scenario may vary from benign to life-threatening. One of the etiological factors that cause PI is the chronic graft-versushost disease (cGVHD), which must be considered in patients with solid organ or hematological malignancies. Especially, patients who received long-term immunosuppressive therapies and were diagnosed with cGVHD are prone to developing a PI. Many patients experience unnecessary operational risks if underdiagnosed. A multidisciplinary approach by the primary physician, general surgeon, and radiology specialist is necessary for the proper treatment of these patients. This case report aimed to discuss the clinical presentation of PI in the course of cGVHD in the intensive care unit. Keywords: Chronic graft versus host disease, pneumatosis intestinalis, intensive care