Discrimination Effectiveness of CK18 on Cell Death Modes in Colon Cancer Cells

Altun Z. S., Akhisaroglu S. T., Batu J., Ateş H., Giray H., Kocturk S.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.35, no.1, pp.20-28, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.20-28
  • Keywords: CK18, cell death, apoptosis, colon cancer, FOLFIRI, DRUG-RESISTANCE, APOPTOSIS, CYTOKERATIN-18, CARCINOMA, NECROSIS, ASSAY, REORGANIZATION, EXPRESSION, INHIBITOR, INDUCTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: Cytokeratin-18 is an intermediate filament that could be a candidate cell death marker in monitoring chemotherapy efficiency. The aim of this study was to evaluate cell death determination effectiveness of CK18 ELISA assay in HCT-116 colon cancer cells treated with clinical compatible dosages of FOLFIRI chemotherapy combination.