Construction of Hexahydropyrido[3,2-c]carbazole and Hexahydropyrrolo[3,2-c]carbazole Skeletons for the Synthesis of Related Indole Alkaloids

GÜNDOĞDU HIZLIATEŞ C., Gulle S.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.53, sa.5, ss.1584-1588, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/jhet.2467
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1584-1588
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Synthesis of tetracyclic hexahydropyrido[3,2-[c] carbazoles (9a and 9b) and hexahydropyrrolo[3,2-[c]carbazoles (13a and 13b) structures was achieved via a new synthetic approach for the synthesis of related indole alkaloids such as deethylaspidospermidine and deethylibophyllidine. Hexahydropyrrolo[3,2-[c] carbazole structure was constructed for the first time starting from ethyl 4-[oxo-[cyclohexanecarboxylate in seven steps. Some tetrahydrocarbazole derivatives (4, 5, 6, 7, 11, and 12) were also synthesized.