The Relationships between Serum sTWEAK, FGF-23 Levels, and Carotid Atherosclerosis in Renal Transplant Patients

Gungor O., Kismali E., Sisman A., Kircelli F., Carrero J. J., Tatar E., ...Daha Fazla

RENAL FAILURE, cilt.35, sa.1, ss.77-81, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/0886022x.2012.734890
  • Dergi Adı: RENAL FAILURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.77-81
  • Anahtar Kelimeler: sTWEAK, FGF-23, atherosclerosis, renal transplantation, INTIMA-MEDIA THICKNESS, CHRONIC KIDNEY-DISEASE, GROWTH-FACTOR 23, HEMODIALYSIS-PATIENTS, MULTIFUNCTIONAL CYTOKINE, CARDIOVASCULAR-DISEASE, WEAK INDUCER, TWEAK, ARTERY, PROLIFERATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Cardiovascular disease is the main cause of mortality after renal transplantation. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and fibroblast growth factor-23 (FGF-23) are two novel molecules that have been associated with atherosclerosis in different populations. In this cross-sectional study, we investigated the associations between sTWEAK, FGF-23, and carotid artery intima-media thickness (CA-IMT) in renal transplant patients. Methods: A total of 117 renal transplant patients were studied. CA-IMT was determined by B-mode Doppler ultrasonography. Serum sTWEAK and FGF-23 were measured by a commercially available enzyme-linked immunosorbent assay (ELISA). Results: Mean age was 39.6 +/- 9.6 years and 51% of the patients were male. Mean sTWEAK level was 595 +/- 225 pg/mL (158-1140), FGF-23 level was 92 +/- 123 RU/mL (9.6-1006), and CA-IMT level was 0.62 +/- 0.11 mm (0.40-0.98). sTWEAK level was positively correlated with CA-IMT. There was no association between sTWEAK and FGF-23 levels. FGF-23 was also associated with CA-IMT. In adjusted models using linear regression analysis, only age and serum TWEAK levels were predictors for CA-IMT. Conclusion: There is a positive correlation between CA-IMT and sTWEAK, but not with FGF-23 levels in renal transplant patients.