Akademik Veri Yönetim Sistemi
Dicle Üniversitesi Veteriner Fakültesi Dergisi, cilt.12, sa.1, ss.46-52, 2019 (Hakemli Dergi)
The negative impact of multiple ascending doses of cefquinome (CFQ) on hematological and serum biochemical profile of horseunknown. The objective of this study was to evaluate the effect of multiple ascending doses of cefquinome (CFQ) in horses on thefollowing hematological (WBCs, LYM, MON, GRA, RBCs, HB, HT, MCV, MCH, MCHC, RDW, and PLT) and biochemical parameters (ALB,ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG, and BUN). The study was performed on the sixteen mature horses (4.6 ± 2.1 years, 302 ±38 kg). Four dosages of CFQ were applied as Group I; 1 mg/kg, Group II; 2 mg/kg, Group III; 4 mg/kg and Group IV; 6 mg/kg, and eachanimal received intravenously a total of 13 injections, administered every 12 h for 7 days. The hematological and biochemicalparameters of horses were monitored on the before 0 day and 1, 3, 7, and 14 days after the administration of the first CFQ. Nosignificant differences in serum biochemical parameters were found amongst the groups (p>0.05). Significant differences were found incertain hematological parameters (MONO, GRAN, RBC, HB, HCT, MCH, and PCT) amongst the groups (p<0.05) within the referenceranges. These results indicate that the administration of multiple doses of up to 6 mg/kg of CFQ in the horse had no clinically significantimpact on the blood parameters measured.