Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Trial

Solomon, Scott; Claggett, Brian; Desai, Akshay; Packer, Milton; Zile, Michael; Swedberg, Karl; Rouleau, Jean; Shi, Victor; Starling, Randall; Kozan, Omer; Dukat, Andrej; Lefkowitz, Martin; McMurray, John

doi:10.1161/circheartfailure.115.002744

Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Trial

Solomon S. D., Claggett B., Desai A. S., Packer M., Zile M., Swedberg K., ...Daha Fazla

CIRCULATION-HEART FAILURE, cilt.9, sa.3, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9 Sayı: 3
Basım Tarihi: 2016
Doi Numarası: 10.1161/circheartfailure.115.002744
Dergi Adı: CIRCULATION-HEART FAILURE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: heart, heart failure, humans, mineralocorticoid receptor antagonists, neprilysin
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background The angiotensin receptor neprilysin inhibitor sacubitril/valsartan (LCZ696) reduced cardiovascular morbidity and mortality compared with enalapril in patients with heart failure (HF) and reduced ejection fraction (EF) in the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. We evaluated the influence of EF on clinical outcomes and on the effectiveness of sacubitril/valsartan compared with enalapril.