Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction

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Demir O., Murat N., Aslan G., Gidener S., Esen A. A.

JOURNAL OF UROLOGY, vol.175, no.6, pp.2345-2349, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 175 Issue: 6
• Publication Date: 2006
• Doi Number: 10.1016/s0022-5347(06)00281-3
• Journal Name: JOURNAL OF UROLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.2345-2349
• Keywords: penis, impotence, prostatic hyperplasia, doxazosin, Y 27632, BENIGN PROSTATIC HYPERPLASIA, TRACT SYMPTOMS LUTS, NITRIC-OXIDE, DYSFUNCTION, CONTRACTILITY, RELAXATION, RABBITS, Y-27632, TONE
• Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: We investigated the relationship of adrenergic responses in corpus cavernosum tissues in the presence of BOO using the alpha 1-adrenergic receptor antagonist doxazosin (Pfizer, New York, New York) and the rho-kinase inhibitor Y-27632 (Calbiochem, San Diego, California).