The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses

Yener G., Fide E., Ozbek Y., EMEK SAVAŞ D. D., AKTÜRK T., ÇAKMUR R., ...More

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, vol.139, pp.48-58, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 139
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ijpsycho.2019.03.002
  • Journal Name: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.48-58
  • Keywords: Event-related, Phase-locking, Power, Oscillation, Theta, Mild cognitive impairment, Parkinson, Alzheimer
  • Dokuz Eylül University Affiliated: Yes

Abstract

Event-related oscillatory responses reflect the cognitive status in many neuropsychiatric conditions including mild cognitive impairment (MCI). In this study, a total of 30 patients with amnestic MCI (aMCI) and 25 patients with MCI of Parkinson's disease (PD-MCI) were compared with 28 aged-, gender-, education-matched healthy control (HC) participants using visual event-related delta, theta, alpha oscillatory responses by methods of event related spectral perturbation and inter-trial coherence. PD-MCI and aMCI groups commonly share a decreased theta power, but all electrophysiological deviations from the controls were more prominent in PD-MCI than aMCI in all frequency bands. Additionally, decreased phase-locking in all studied frequency bands was encountered only in PD-MCI group, but it was preserved in aMCI. These findings indicate that visual networks in PD-MCI are more severely affected than aMCI. Reduced phase-locking in PD-MCI may possibly relate to dysfunctioning subcortical modulating centers that take a role in the generation of event-related responses.