Histologic grading of noninvasive papillary urothelial neoplasms

MacLennan G. T., Kirkali Z., Cheng L.

EUROPEAN UROLOGY, cilt.51, sa.4, ss.889-898, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.eururo.2006.10.037
  • Dergi Adı: EUROPEAN UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.889-898
  • Anahtar Kelimeler: grading, neoplasia, papillary urothelial neoplasm of low malignant potential (PUNLMP), transitional cell carcinoma, urinary bladder, WHO/ISUP classification
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objectives: In 1998, a revised system of classifying noninvasive papillary urothelial neoplasms of the urinary bladder was proposed and subsequently formally adopted by the World Health Organization (WHO). The introduction of this new system was justified as being potentially superior on a number of levels to the 1973 WHO classification system that it replaced. Specifically, a new category of neoplasms, designated papillary urothelial neoplasm of low malignant potential (PUNLMP), was considered advantageous for several reasons. The new system was expected to gain widespread acceptance, improve reproducibility of diagnoses among pathologists, and enhance the correlation between urine cytology and tumor histology. We examine the history of the changes in terminology for these lesions, the relative merits of PUNLMP terminology, the extent to which the expectations accompanying the new grading system have been met, and the extent to which the new system has enhanced the management of patients with noninvasive papillary urothelial neoplasms of the bladder.